Mass Spectrometry of Protein Interactions (ISBN: 978-0-471-79373-1) is a leading new text published by Wiley that is the first to be published on the subject (published August 2007)
Mass spectrometry (MS) is the major analytical technology for protein identification, sequencing, and quantitation, and is central to discoveries in proteomics. Advances in recent years, have positioned mass spectrometry as an important approach with which to study protein complexes and assemblies, either through their direct detection by ESI and MALDI-MS and/or following chemical and enzymatic treatments.
Mass Spectrometry of Protein Interactions provides mass spectrometrists, as well as protein scientists and other biologists with an up-to-date account of the development and application of mass spectrometry for investigating protein interactions through a range of approaches. Each chapter is written by international authorities, and in some cases pioneers, of the approaches and features amble illustrations and references to the primary literature.
Chapters:
- Through the Looking Glass - Protein Interactions as Viewed by Mass Spectrometry
- Direct Characterization of Protein Complexes by Electrospray Ionization Mass Spectrometry and Ion Mobility Analysis
- Softly, Softly. Detection of Protein Complexes by Matrix-Assisted Laser Desorption Ionisation Mass Spectrometry
- Probing Protein Interactions Using Hydrogen-Deuterium Exchange Mass Spectrometry
- Limited Proteolysis Mass Spectrometry of Protein Complexes
- Chemical Cross-Linking and Mass Spectrometry for Investigation of Protein-Protein Interactions
- Genesis & Application of Radical Probe Mass Spectrometry (RP-MS) to Study Protein Interactions
Contributors:
| Kevin M. Downard (editor), Australia |
Maria Monti, Italy |
| John R. Engen, USA |
Piero Pucci, Italy |
| Catherine S. Kaddis, USA |
Andrea Sinz, Germany |
| Suma Kaveti, USA |
David D. Weis, USA |
| Joseph A. Loo, USA |
Yan Wu, USA |
| Simin D. Maleknia, Australia |
|
Review (excerpt):
"A comprehensive guide to the analysis of protein interactions by mass spectrometry (and) a valuable contribution to the current literature ... The contributions are written in a concise style and highlight the state of the art in the respective methodologies, but also point out shortcomings and challenges. Each chapter serves as an extensive resource of references to the primary literature."
Jurgen Cox, ChemBioChem (2008) 9: 644-645
