Dr Andrew James Holmes
Molecular and Microbial Biosciences G08 - Biochemistry and Microbiology Building
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Microorganisms are the most abundant and the most diverse group of organisms on Earth. They are also the most poorly known. As such the microbiota represent the largest unexplored biological resource on Earth. Andrew's research interests focus on three distinct aspects of microbial diversity:
1. The role of gut microbial diversity in human health;
2. Exploring microbial diversity for new biological resources;
3. The underlying evolutionary origins of microbial diversity
1. The role of gut microbial diversity in human health;
2. Exploring microbial diversity for new biological resources;
3. The underlying evolutionary origins of microbial diversity
- Chew, Y, Holmes, A. Suppression subtractive hybridisation allows selective sampling of metagenomic subsets of interest. Journal of microbiological methods. 2009; 78:136-43 [Abstract]
- Thompson, C, Holmes, A. A window of environmental dependence is evident in multiple phylogenetically distinct subgroups in the faecal community of piglets. FEMS microbiology letters. 2009; 290:91-7 [Abstract]
- Tetu, S, Holmes, A. A Family Of Insertion Sequences That Impacts Integrons By Specific Targeting Of Gene Cassette Recombination Sites, The IS1111-attc Group. Journal of bacteriology. 2008; 190:4959-70 [Abstract]
- Gillings, M, Boucher, Y, Labbate, M, Holmes, A, Krishnan, S, Holley, M, Stokes, H. The Evolution of Class 1 Integrons and the Rise of Antibiotic Resistance. Journal of bacteriology. 2008; 190:5095-100 [Abstract]
- Thompson, C, Wang, B, Holmes, A. The immediate environment during postnatal development has long-term impact on gut community structure in pigs. The ISME journal. 2008; 2:739-48 [Abstract]
- Holmes, A, Coleman, N. Evolutionary ecology and multidisciplinary approaches to prospecting for monooxygenases as biocatalysts. Antonie van Leeuwenhoek. 2008; 94:75-84 [Abstract]
- Holmstrom, C, Taylor, M, Kjelleberg, S, Steinberg, P, Crocetti, G, Tujula, N, Longford, S, Holmes, A. Comparisons of diversity of bacterial communities associated with three sessile marine eukaryotes. AQUATIC MICROBIAL ECOLOGY. 2007; 48:217-229 [Abstract]
- Roy, P, Stokes, H, Hall, R, Holmes, A. What are superintegrons?. NATURE REVIEWS MICROBIOLOGY. 2007; 5:1-2 [Abstract]
- Coleman, N, Bui, N, Holmes, A. Soluble di-iron monooxygenase gene diversity in soils, sediments and ethene enrichments. Environmental microbiology. 2006; 8:1228-39 [Abstract]
- Coleman, N, Holmes, A. The native Pseudomonas stutzeri strain Q chromosomal integron can capture and express cassette-associated genes. Microbiology (Reading, England). 2005; 151:1853-64 [Abstract]
- Gillings, M, Holley, M, Stokes, H, Holmes, A. Integrons in Xanthomonas: a source of species genome diversity. Proceedings of the National Academy of Sciences of the United States of America. 2005; 102:4419-24 [Abstract]
Integrons; Pseudomonas stutzeri; Xanthomonas