School of Molecular and Microbial Biosciences
The University of Sydney
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Dr William Arthur Bubb

Senior Research Fellow
Molecular and Microbial Biosciences
Faculty of Science

G08 - Biochemistry and Microbiology Building
The University of Sydney
NSW 2006 Australia

Email
Phone 61 2 9351 4120
Fax 61-2-9351-4726
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Research Interests

Biochemical/biophysical applications of NMR spectroscopy

Select Publications

    2008
    • Torres, A, Bubb, W, Philp, D, Kuchel, P. Improved J-compensated sequences based on short composite pulses. Journal of magnetic resonance (San Diego, Calif. : 1997). 2008; 194:81-8 [Abstract]
    • Larkin, T, Bubb, W, Kuchel, P. Water chemical shift in 1H NMR of red cells: effects of pH when transmembrane magnetic susceptibility differences are low. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. 2008; 59:707-11 [Abstract]
    2007
    • Plummer, R, Bodkin, J, Power, D, Pantarat, N, Bubb, W, Kuchel, P, Sorrell, T. Effect of Caspofungin on Metabolite Profiles of Aspergillus Species Determined by Nuclear Magnetic Resonance Spectroscopy. Antimicrobial agents and chemotherapy. 2007; 51:4077-84 [Abstract]
    • Plummer, R, Bodkin, J, Yau, T, Power, D, Pantarat, N, Larkin, T, Szekely, D, Bubb, W, Sorrell, T, Kuchel, P. Modelling Staphylococcus aureus-induced septicemia using NMR. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. 2007; 58:656-665 [Abstract]
    • Bröer, S, Bröer, A, Hansen, J, Bubb, W, Balcar, V, Nasrallah, F, Garner, B, Rae, C. Alanine metabolism, transport, and cycling in the brain. Journal of neurochemistry. 2007; 102:1758-1770 [Abstract]
    • Naumann, C, Bubb, W, Chapman, B, Kuchel, P. Tunable-alignment chiral system based on gelatin for NMR spectroscopy. Journal of the American Chemical Society. 2007; 129:5340-5341 [Abstract]
    • Larkin, T, Bubb, W, Kuchel, P. pH and cell volume effects on H2O and phosphoryl resonance splitting in rapid-spinning NMR of red cells. Biophysical journal. 2007; 92:1770-6 [Abstract]
    • Moussa, C, Rae, C, Bubb, W, Griffin, J, Deters, N, Balcar, V. Inhibitors of glutamate transport modulate distinct patterns in brain metabolism. Journal of neuroscience research. 2007; 85:342-50 [Abstract]
    2006
    • Coen, M, Bodkin, J, Power, D, Bubb, W, Himmelreich, U, Kuchel, P, Sorrell, T. Antifungal effects on metabolite profiles of medically important yeast species measured by nuclear magnetic resonance spectroscopy. Antimicrobial agents and chemotherapy. 2006; 50:4018-26 [Abstract]
    • Parekh, S, Bubb, W, Hunt, N, Rae, C. Brain metabolic markers reflect susceptibility status in cytokine gene knockout mice with murine cerebral malaria. International journal for parasitology. 2006; 36:1409-18 [Abstract]
    • Rae, C, Moussa, C, Griffin, J, Parekh, S, Bubb, W, Hunt, N, Balcar, V. A metabolomic approach to ionotropic glutamate receptor subtype function: a nuclear magnetic resonance in vitro investigation. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2006; 26:1005-17 [Abstract]
    • Szekely, D, Chapman, B, Bubb, W, Kuchel, P. Rapid Exchange of Fluoroethylamine via the Rhesus Complex in Human Erythrocytes: (19)F NMR Magnetization Transfer Analysis Showing Competition by Ammonia and Ammonia Analogues. Biochemistry. 2006; 45:9354-61 [Abstract]
    • Agon, V, Bubb, W, Wright, A, Hawkins, C, Davies, M. Sensitizer-mediated photo-oxidation of histidine residues: Evidence for the formation of reactive side-chain peroxides (vol 40, pg 698, 2006). Free Radical Biology and Medicine. 2006; 40:2242-2242 [Abstract]
    • Kuchel, P, Chapman, B, Müller, N, Bubb, W, Philp, D, Torres, A. Apparatus for rapid adjustment of the degree of alignment of NMR samples in aqueous media: verification with residual quadrupolar splittings in (23)Na and (133)Cs spectra. Journal of magnetic resonance (San Diego, Calif. : 1997). 2006; 180:256-65 [Abstract]
    • Agon, V, Bubb, W, Wright, A, Hawkins, C, Davies, M. Sensitizer-mediated photooxidation of histidine residues: evidence for the formation of reactive side-chain peroxides. Free radical biology & medicine. 2006; 40:698-710 [Abstract]
    2005
    • Coen, M, O'Sullivan, M, Bubb, W, Kuchel, P, Sorrell, T. Proton nuclear magnetic resonance-based metabonomics for rapid diagnosis of meningitis and ventriculitis. Clinical infectious diseases: an official publication of the Infectious Diseases Society of America. 2005; 41:1582-90 [Abstract]
    • Parekh, S, Moussa, C, Balcar, V, Hunt, N, Bubb, W, Rae, C. Quinolinic acid, kynurenic acid and dserine stimulate brain metabolism. Journal of Neurochemistry. 2005; 94:58-58 [Abstract]
    • Kennett, E, Ogawa, E, Agar, N, Godwin, I, Bubb, W, Kuchel, P. Investigation of methaemoglobin reduction by extracellular NADH in mammalian erythrocytes. The international journal of biochemistry & cell biology. 2005; 37:1438-45 [Abstract]
    • Rae, C, Moussa, C, Griffin, J, Bubb, W, Wallis, T, Balcar, V. Group I and II metabotropic glutamate receptors alter brain cortical metabolic and glutamate/glutamine cycle activity: a 13C NMR spectroscopy and metabolomic study. Journal of neurochemistry. 2005; 92:405-16 [Abstract]
    • Kennett, E, Bubb, W, Bansal, P, Alewood, P, Kuchel, P. NMR studies of exchange between intra- and extracellular glutathione in human erythrocytes. Redox report: communications in free radical research. 2005; 10:83-90 [Abstract]
    2004
    • Kuchel, P, Bubb, W, Ramadan, S, Chapman, B, Philp, D, Coen, M, Gready, J, Harvey, P, McLean, A, Hook, J. 31P MAS-NMR of human erythrocytes: independence of cell volume from angular velocity. Magnetic Resonance in Medicine. 2004; 52:663-668 [Abstract]
    • Rae, C, McQuillan, J, Parekh, S, Bubb, W, Weiser, S, Balcar, V, Hansen, A, Ball, H, Hunt, N. Brain gene expression, metabolism, and bioenergetics: interrelationships in murine models of cerebral and noncerebral malaria. The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2004; 18:499-510 [Abstract]
    • Wallis, T, Bubb, W, McQuillan, J, Balcar, V, Rae, C. For want of a nail. ramifications of a single gene deletion, dystrophin, in the brain of the mouse. Frontiers in bioscience : a journal and virtual library. 2004; 9:74-84 [Abstract]
    2003
    • Rae, C, Hare, N, Bubb, W, McEwan, S, Bröer, A, McQuillan, J, Balcar, V, Conigrave, A, Bröer, S. Inhibition of glutamine transport depletes glutamate and GABA neurotransmitter pools: further evidence for metabolic compartmentation. Journal of neurochemistry. 2003; 85:503-14 [Abstract]
    • Kuchel, P, Chapman, B, Bubb, W, Hansen, P, Durrant, C, Hertzberg, M. Magnetic susceptibility: Solutions, emulsions, and cells. Concepts in Magnetic Resonance Part A. 2003; 18A:56-71
    • Balasundram, N, Bubb, W, Sundram, K, Samman, S. Antioxidants from palm (Elaeis guineensis) fruit extracts. Asia Pacific journal of clinical nutrition.. 2003; 12 Suppl:S37 [Abstract]
    • Rae, C, McQuillan, J, Parekh, S, Bubb, W, Weiser, S, Balcar, V, Hansen, A, Ball, H, Hunt, N. Brain gene expression, metabolism, and bioenergetics: interrelationships in murine models of cerebral and noncerebral malaria. Faseb Journal. 2003; 18:499-510
    • Stanton, D, Liao, L, Moussa, C, Bubb, W, Rae, C, Balcar, V. Can inhibition of glutamate transport contribute to the actions of neuroleptics?. Psychiatrie. 2003; 7:6-11
    • Wallis, T, Bubb, W, McQuillan, J, Balcar, V, Rae, C. For want of a nail. Ramifications of a single gene deletion, dystrophin, in the brain of the mouse. Frontiers In Bioscience. 2003; 9:74-84
    2002
    • Wright, L, Bubb, W, Davidson, J, Santangelo, R, Krockenberger, M, Himmelreich, U, Sorrell, T. Metabolites released by Cryptococcus neoformans var. neoformans and var. gattii differentially affect human neutrophil function. Microbes and infection / Institut Pasteur. 2002; 4:1427-38 [Abstract]
    • Wright, A, Bubb, W, Hawkins, C, Davies, M. Singlet oxygen-mediated protein oxidation: evidence for the formation of reactive side chain peroxides on tyrosine residues. Photochemistry and photobiology. 2002; 76:35-46 [Abstract]
    • Torres, A, Bubb, W, Kuchel, P. Experiments to detect long-range heteronuclear shift correlations: LR-J-HSMQC. Journal of magnetic resonance (San Diego, Calif. : 1997). 2002; 156:249-57 [Abstract]
    • Rae, C, Griffin, J, Blair, D, Bothwell, J, Bubb, W, Maitland, A, Head, S. Abnormalities in brain biochemistry associated with lack of dystrophin: studies of the mdx mouse. Neuromuscular disorders : NMD. 2002; 12:121-9 [Abstract]
    • Moussa, C, Mitrovic, A, Vandenberg, R, Provis, T, Rae, C, Bubb, W, Balcar, V. Effects of L-glutamate transport inhibition by a conformationally restricted glutamate analogue (2S,1'S,2'R)-2-(carboxycyclopropyl)glycine (L-CCG III) on metabolism in brain tissue in vitro analysed by NMR spectroscopy. Neurochemical research. 2002; 27:27-35 [Abstract]
    2000
    • Rae, C, Maitland, D, Bubb, W, Hunt, N. Dichloroacetate (DCA) reduces brain lactate but increases brain glutamine in experimental cerebral malaria: a 1H-NMR study. Redox Report. 2000; 5:141-143
    • Rae, C, Lawrence, M, Dias, L, Provis, T, Bubb, W, Balcar, V. Strategies for studies of neurotoxic mechanisms involving deficient transport of L-glutamate: antisense knockout in rat brain in vivo and changes in the neurotransmitter metabolism following inhibition of glutamate transport in guinea pig brain slices. Brain Research Bulletin. 2000; 53:373-381

    Publication Keywords

    Erythrocytes; Energy Metabolism; Malaria; Analytical; Diagnostic and Therapeutic Techniques and Equipment; Chemicals and Drugs