Associate Professor Charles Collyer
Associate Dean G08 - Biochemistry and Microbiology Building
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Charles' research focuses on the fundamental relationship between the atomic structure of molecules and how they function in cells. The method of Protein Crystallography has made a major contribution to our understanding of enzyme mechanism, molecular recognition, and to our growing knowledge of the mechanics of molecular machines. Research projects in structural biology are aimed to contribute to areas such as drug design and protein engineering. A key focus of his recent efforts has been in the application of protein crystallography to biomedical research.
- Yap, B, Simpkins, G, Collyer, C, Hunter, N, Crossley, M. Porphyrin-linked nitroimidazole antibiotics targeting Porphyromonas gingivalis. Organic & biomolecular chemistry. 2009; 7:2855-63 [Abstract]
- Langley, D, Harty, D, Jacques, N, Hunter, N, Guss, J, Collyer, C. Structure of N-acetyl-beta-D-glucosaminidase (GcnA) from the Endocarditis Pathogen Streptococcus gordonii and its Complex with the Mechanism-based Inhibitor NAG-thiazoline. Journal of molecular biology. 2008; 377:104-16 [Abstract]
- Park, J, Knott, H, Nadvi, N, Collyer, C, Wang, X, Church, B, Gorrell, M. Reversible Inactivation of Human Dipeptidyl Peptidases 8 and 9 by Oxidation. The Open Enzyme Inhibition Journal. 2008; 1:52-60
- Jeffries, C, Graham, S, Stokes, P, Collyer, C, Guss, J, Matthews, J. Stabilization of a binary protein complex by intein-mediated cyclization. Protein science : a publication of the Protein Society. 2006; 15:2612-8 [Abstract]
- Mun, H, Culverston, E, Franks, A, Collyer, C, Clifton-Bligh, R, Conigrave, A. A double mutation in the extracellular Ca2+-sensing receptor's venus flytrap domain that selectively disables L-amino acid sensing. The Journal of biological chemistry. 2005; 280:29067-72 [Abstract]
- Templeton, M, Reinhardt, L, Collyer, C, Mitchell, R, Cleland, W. Kinetic analysis of the L-ornithine transcarbamoylase from Pseudomonas savastanoi pv. phaseolicola that is resistant to the transition state analogue (R)-N delta-(N'-sulfodiaminophosphinyl)-L-ornithine. Biochemistry. 2005; 44:4408-15 [Abstract]
- Yun, P, Decarlo, A, Chapple, C, Collyer, C, Hunter, N. Binding of Porphyromonas gingivalis gingipains to human CD4(+) T cells preferentially down-regulates surface CD2 and CD4 with little affect on co-stimulatory molecule expression. Microbial pathogenesis. 2005; 38:85-96 [Abstract]
- Paramaesvaran, M, Nguyen, K, Caldon, E, McDonald, J, Najdi, S, Gonzaga, G, Langley, D, DeCarlo, A, Crossley, M, Hunter, N, Collyer, C. Porphyrin-mediated cell surface heme capture from hemoglobin by Porphyromonas gingivalis. Journal of Bacteriology. 2003; 185:2528-2537 [Abstract]
- Maher, M, Huang, D, Guss, J, Collyer, C, Christopherson, R. Crystallization of hamster dihydroorotase: involvement of a disulfide-linked tetrameric form. Acta crystallographica. Section D, Biological crystallography. 2003; 59:381-384 [Abstract]
- Kekic, M, Nosworthy, N, Dedova, I, Collyer, C, dos Remedios, C. Regulation of the cytoskeleton assembly: a role for a ternary complex of actin with two actin-binding proteins. Results and Problems in Cell Differentiation. 2001; 32:165-179 [Abstract]
Amino Acids; Antigens, CD4; CD4-Positive T-Lymphocytes; Receptors, Calcium-Sensing; Pseudomonas; Antigens, CD2; Cysteine Endopeptidases; Hemagglutinins; Porphyromonas gingivalis; Ornithine; Ornithine Carbamoyltransferase