Associate Professor Gareth Denyer
Associate Professor G08 - Biochemistry and Microbiology Building
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Gareth main interest is in the molecular mechanisms underlying body 'set point'. He uses DNA microarrays to look at transcriptome patterns in circumstances of metabolic interest- for example:
* how does gene expression change in different tissues when we consume different diets - especially those of different glycemic index?
* how do different hormones (like insulin and leptin) affect which genes are switched on and off?
* what gene expression patterns characterise large and small adipocytes? What happens as adipocytes change in size (as in weight loss and weight gain).
* what gene expression patterns characterise different types of obesity?
To assist with the interpretation of microarray data, he has developed user-friendly analysis tools, and these are widely used by collaborators across the world.
He also has interests in the regulation of intermediary metabolism, nutritional epidemiology and fuel selection during exercise. He is a consultant for the weight loss industry and helps manage Glycemic Index testing services.
In addition he is an enthusiastic database developer and has created systems for:
* Dietary communication and meal analysis for the Sydney 2000 Olympic Games
* Sydney University Glycemic Index Research Services and Metabolism and Obesity services at Royal Prince Alfred Hospital.
* Clinical Research in both Research Institutes and Hospitals
* Dietary assessment and nutritional intervention studies (especially in the area of childhood obesity and on-line shopping)
* Course management and University Administration
* how does gene expression change in different tissues when we consume different diets - especially those of different glycemic index?
* how do different hormones (like insulin and leptin) affect which genes are switched on and off?
* what gene expression patterns characterise large and small adipocytes? What happens as adipocytes change in size (as in weight loss and weight gain).
* what gene expression patterns characterise different types of obesity?
To assist with the interpretation of microarray data, he has developed user-friendly analysis tools, and these are widely used by collaborators across the world.
He also has interests in the regulation of intermediary metabolism, nutritional epidemiology and fuel selection during exercise. He is a consultant for the weight loss industry and helps manage Glycemic Index testing services.
In addition he is an enthusiastic database developer and has created systems for:
* Dietary communication and meal analysis for the Sydney 2000 Olympic Games
* Sydney University Glycemic Index Research Services and Metabolism and Obesity services at Royal Prince Alfred Hospital.
* Clinical Research in both Research Institutes and Hospitals
* Dietary assessment and nutritional intervention studies (especially in the area of childhood obesity and on-line shopping)
* Course management and University Administration
- Reynolds, R, Stockmann, K, Atkinson, F, Denyer, G, Brand-Miller, J. Effect of the glycemic index of carbohydrates on day-long (10 h) profiles of plasma glucose, insulin, cholecystokinin and ghrelin. European journal of clinical nutrition. 2009; 63:872-8 [Abstract]
- Gosby, A, Stanton, L, Maloney, C, Thompson, M, Briody, J, Baxter, R, Bryson, J, Denyer, G, Caterson, I. Postnatal nutrition alters body composition in adult offspring exposed to maternal protein restriction. The British journal of nutrition. 2009; 101:1878-84 [Abstract]
- Wang, Y, Mulligan, C, Denyer, G, Delom, F, Dagna-Bricarelli, F, Tybulewicz, V, Fisher, E, Griffiths, W, Nizetic, D, Groet, J. Quantitative proteomic characterisation of a mouse embryonic stem cell model of Down syndrome. Molecular & cellular proteomics : MCP. 2009; 8:585-95 [Abstract]
- Brand-Miller, J, Stockmann, K, Atkinson, F, Petocz, P, Denyer, G. Glycemic index, postprandial glycemia, and the shape of the curve in healthy subjects: analysis of a database of more than 1000 foods. The American journal of clinical nutrition. 2009; 89:97-105 [Abstract]
- Canzonetta, C, Mulligan, C, Deutsch, S, Ruf, S, O'Doherty, A, Lyle, R, Borel, C, Lin-Marq, N, Delom, F, Groet, J, Schnappauf, F, De Vita, S, Averill, S, Priestley, J, Martin, J, Shipley, J, Denyer, G, Epstein, C, Fillat, C, Estivill, X, Tybulewicz, V, Fisher, E, Antonarakis, S, Nizetic, D. DYRK1A-dosage imbalance perturbs NRSF/REST levels, deregulating pluripotency and embryonic stem cell fate in Down syndrome. American Journal of Human Genetics. 2008; 83:388-400 [Abstract]
- Yu, P, Passam, F, Yu, D, Denyer, G, Krilis, S. beta2-Glycoprotein I inhibits vascular endothelial growth factor and basic fibroblast growth factor induced angiogenesis through its amino terminal domain. Journal of thrombosis and haemostasis : JTH. 2008; 6:1215-23 [Abstract]
- Sue, N, Jack, B, Eaton, S, Pearson, R, Funnell, A, Turner, J, Czolij, R, Denyer, G, Bao, S, Molero-Navajas, J, Perkins, A, Fujiwara, Y, Orkin, S, Bell-Anderson, K, Crossley, M. Targeted disruption of the Basic Kruppel-like Factor (Klf3) gene reveals a role in adipogenesis. Molecular and cellular biology. 2008; 28:3967-78 [Abstract]
- Wolever, T, Brand-Miller, J, Abernethy, J, Astrup, A, Atkinson, F, Axelsen, M, Björck, I, Brighenti, F, Brown, R, Brynes, A, Casiraghi, M, Cazaubiel, M, Dahlqvist, L, Delport, E, Denyer, G, Erba, D, Frost, G, Granfeldt, Y, Hampton, S, Hart, V, Hätönen, K, Henry, C, Hertzler, S, Hull, S, Jerling, J, Johnston, K, Lightowler, H, Mann, N, Morgan, L, Panlasigui, L, Pelkman, C, Perry, T, Pfeiffer, A, Pieters, M, Ramdath, D, Ramsingh, R, Robert, S, Robinson, C, Sarkkinen, E, Scazzina, F, Sison, D, Sloth, B, Staniforth, J, Tapola, N, Valsta, L, Verkooijen, I, Weickert, M, Weseler, A, Wilkie, P, Zhang, J. Measuring the glycemic index of foods: interlaboratory study. The American journal of clinical nutrition. 2008; 87:247S-257S [Abstract]
- Both, M, Caterson, I, Hill, A, Franklin, J, Steinbeck, K, Denyer, G. Preadolescents who fat bully others. INTERNATIONAL JOURNAL OF OBESITY. 2007; 31:S39-S39 [Abstract]
- Woltring, D, Shannon, M, Gerondakis, S, Denyer, G, Hardy, K, Rao, S, Bunting, K, Wang, J. Genome-wide analysis of gene expression in T cells to identify targets of the NF-kappa B transcription factor c-Rel. JOURNAL OF IMMUNOLOGY. 2007; 178:7097-7109 [Abstract]
- Franklin, J, Denyer, G, Steinbeck, K, Caterson, I, Hill, A. Obesity and Risk of Low Self-esteem: A Statewide Survey of Australian Children. Pediatrics. 2006; 118:2481-7 [Abstract]
- Nguyen, L, Kriketos, A, Hancock, D, Caterson, I, Denyer, G. Insulin resistance does not influence gene expression in skeletal muscle. Journal of biochemistry and molecular biology. 2006; 39:457-63 [Abstract]
- Singh, J, Manickam, P, Shmoish, M, Natik, S, Denyer, G, Handelsman, D, Gong, D, Dong, Q. Annotation of androgen dependence to human prostate cancer-associated genes by microarray analysis of mouse prostate. Cancer letters. 2006; 237:298-304 [Abstract]
- Hancock, D, Nguyen, L, Denyer, G, Johnston, J. Microarrays for undergraduate classes. Biochemistry and Molecular Biology Education. 2006; 34:432-437 [Abstract]
- Huang, A, Barzi, F, Huxley, R, Denyer, G, Rohrlach, B, Jayne, K, Neal, B. The Effects on Saturated Fat Purchases of Providing Internet Shoppers with Purchase- Specific Dietary Advice: A Randomised Trial. PLoS clinical trials. 2006; 1:e22 [Abstract]
- Busch, A, Gurisik, E, Cordery, D, Sudlow, M, Denyer, G, Laybutt, D, Hughes, W, Biden, T. Increased fatty acid desaturation and enhanced expression of stearoyl coenzyme A desaturase protects pancreatic beta-cells from lipoapoptosis. Diabetes. 2005; 54:2917-24 [Abstract]
- Kriketos, A, Denyer, G, Thompson, C, Campbell, L. Intramyocellular lipid is not significantly increased in healthy young insulin resistant first-degree relatives of diabetic subjects. Diabetes care. 2005. p. 2332-3. [Abstract]
- Walker, C, Bryson, J, Bell-Anderson, K, Hancock, D, Denyer, G, Caterson, I. Insulin determines leptin responses during a glucose challenge in fed and fasted rats. International Journal of Obesity. 2005; 29:398-405 [Abstract]
- Kriketos, A, Milner, K, Denyer, G, Campbell, L. Is postprandial hypertriglyceridaemia in relatives of type 2 diabetic subjects a consequence of insulin resistance?. European journal of clinical investigation. 2005; 35:117-25 [Abstract]
- Gosby, A, Maloney, C, Phuyal, J, Denyer, G, Bryson, J, Caterson, I. Maternal protein restriction increases hepatic glycogen storage in young rats. Pediatric research. 2003; 54:413-8 [Abstract]
- Maloney, C, Gosby, A, Phuyal, J, Denyer, G, Bryson, J, Caterson, I. Site-specific changes in the expression of fat-partitioning genes in weanling rats exposed to a low-protein diet in utero. Obesity research. 2003; 11:461-8 [Abstract]
Insulin Resistance; Leptin; Insulin; Diabetes Mellitus, Type 2; Glucose; Lipids; Hypertriglyceridemia; Islets of Langerhans; Diabetes Mellitus; Fatty Acids; Fasting; Fatty Acid Desaturases; Palmitic Acid; Stearoyl-CoA Desaturase; Transcription; Genetic