Dr Joel Mackay

NHMRC Senior Research Fellow Molecular and Microbial Biosciences Faculty of Science G08 - Biochemistry and Microbiology Building The University of Sydney NSW 2006 Australia Email Phone + 61 2 9351 3906 Fax +61 2 9351 4726  Related Website		Quick Links List Profiles Update Your Profile How to update your profile

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• Loughlin, F, Lee, M, Guss, J, Mackay, J. Crystallization of a ZRANB2-RNA complex. Acta crystallographica. Section F, Structural biology and crystallization communications. 2008; 64:1175-1177 [Abstract]
• Kwan, A, Macindoe, I, Vukasin, P, Morris, V, Kass, I, Gupte, R, Mark, A, Templeton, M, Mackay, J, Sunde, M. The Cys3-Cys4 Loop of the Hydrophobin EAS Is Not Required for Rodlet Formation and Surface Activity. Journal of molecular biology. 2008; 382:708-20 [Abstract]
• Sunde, M, Kwan, A, Templeton, M, Beever, R, Mackay, J. Structural analysis of hydrophobins. Micron (Oxford, England : 1993). 2008; 39:773-84 [Abstract]
• Liew, C, Gamsjaeger, R, Mansfield, R, Mackay, J. NMR spectroscopy as a tool for the rapid assessment of the conformation of GST-fusion proteins. Protein Science. 2008; 17:1630-1635 [Abstract]
• Matthews, J, Loughlin, F, Mackay, J. Designed metal-binding sites in biomolecular and bioinorganic interactions. Current opinion in structural biology. 2008; 18:484-90 [Abstract]
• Bhati, M, Lee, C, Nancarrow, A, Lee, M, Craig, V, Bach, I, Guss, J, Mackay, J, Matthews, J. Implementing the LIM code: the structural basis for cell type-specific assembly of LIM-homeodomain complexes. The EMBO journal. 2008; 27:2018-29 [Abstract]
• Griffin, M, Dobson, R, Pearce, F, Antonio, L, Whitten, A, Liew, C, Mackay, J, Trewhella, J, Jameson, G, Perugini, M, Gerrard, J. Evolution of quaternary structure in a homotetrameric enzyme. Journal of molecular biology. 2008; 380:691-703 [Abstract]
• Mackay, J, Sunde, M, Lowry, J, Crossley, M, Matthews, J. Response to Chatr-aryamontri et al.: Protein interactions: to believe or not to believe?. Trends in biochemical sciences. 2008. p. 242-243. [Abstract]
• Wilkinson, S, Liew, C, Mackay, J, Salleh, H, Withers, S, McLeod, M. Escherichia coli glucuronylsynthase: an engineered enzyme for the synthesis of beta-glucuronides. Organic letters. 2008; 10:1585-88 [Abstract]
• Langley, D, Shojaei, M, Chan, C, Lok, H, Mackay, J, Traut, T, Guss, J, Christopherson, R. Structure and inhibition of orotidine 5'-monophosphate decarboxylase from Plasmodium falciparum. Biochemistry. 2008; 47:3842-3854 [Abstract]
• Gamsjaeger, R, Swanton, M, Kobus, F, Lehtomaki, E, Lowry, J, Kwan, A, Matthews, J, Mackay, J. Structural and biophysical analysis of the DNA-binding properties of myelin transcription factor 1. The Journal of biological chemistry. 2008; 283:5158-67 [Abstract]

• Mackay, J, Sunde, M, Lowry, J, Crossley, M, Matthews, J. Protein interactions: is seeing believing?. Trends in biochemical sciences. 2007. p. 530-1. [Abstract]
• Wang, C, Guncar, G, Forwood, J, Teh, T, Catanzariti, A, Lawrence, G, Loughlin, F, Mackay, J, Schirra, H, Anderson, P, Ellis, J, Dodds, P, Kobe, B. Crystal Structures of Flax Rust Avirulence Proteins AvrL567-A and -D Reveal Details of the Structural Basis for Flax Disease Resistance Specificity. The Plant cell. 2007; 19:2898-2912 [Abstract]
• Kirk, E, Sunde, M, Costa, M, Rankin, S, Wolstein, O, Castro, M, Butler, T, Hyun, C, Guo, G, Otway, R, Mackay, J, Waddell, L, Cole, A, Hayward, C, Keogh, A, Macdonald, P, Griffiths, L, Fatkin, D, Sholler, G, Zorn, A, Feneley, M, Winlaw, D, Harvey, R. Mutations in Cardiac T-Box Factor Gene TBX20 Are Associated with Diverse Cardiac Pathologies, Including Defects of Septation and Valvulogenesis and Cardiomyopathy. American journal of human genetics. 2007; 81:280-91 [Abstract]
• Yu, X, Kong, Y, Dore, L, Abdulmalik, O, Katein, A, Zhou, S, Choi, J, Gell, D, Mackay, J, Gow, A, Weiss, M. An erythroid chaperone that facilitates folding of alpha-globin subunits for hemoglobin synthesis. The Journal of clinical investigation. 2007; 117:1856-65 [Abstract]
• Liew, C, Crossley, M, Mackay, J, Nicholas, H. Solution Structure of the THAP Domain from Caenorhabditis elegans C-terminal Binding Protein (CtBP). Journal of molecular biology. 2007; 366:382-90 [Abstract]
• Gamsjaeger, R, Liew, C, Loughlin, F, Crossley, M, Mackay, J. Sticky fingers: zinc-fingers as protein-recognition motifs. Trends in biochemical sciences. 2007; 32:63-70 [Abstract]
• Grant, R, Crossley, M, Mackay, J. Zinc-finger Genes. Encyclopedia of Life Sciences. 2007; 0:1-8

• Liew, C, Rand, K, Simpson, R, Yung, W, Mansfield, R, Crossley, M, Proetorius-Ibba, M, Nerlov, C, Poulsen, F, Mackay, J. Molecular analysis of the interaction between the hematopoietic master transcription factors GATA-1 and PU.1. The Journal of biological chemistry. 2006; 281:28296-306 [Abstract]
• Gell, D, Westman, B, Gorman, D, Liew, C, Welch, J, Weiss, M, Mackay, J. A Novel Haem-binding Interface in the 22 kDa Haem-binding Protein p22HBP. Journal of molecular biology. 2006; 362:287-97 [Abstract]
• Kook, H, Yung, W, Simpson, R, Kee, H, Shin, S, Lowry, J, Loughlin, F, Yin, Z, Epstein, J, Mackay, J. Analysis of the Structure and Function of the Transcriptional Coregulator HOP(,). Biochemistry. 2006; 45:10584-10590 [Abstract]
• Ryan, D, Sunde, M, Kwan, A, Marianayagam, N, Nancarrow, A, Vanden Hoven, R, Thompson, L, Baca, M, Mackay, J, Visvader, J, Matthews, J. Identification of the key LMO2-binding determinants on Ldb1. Journal of molecular biology. 2006; 359:66-75 [Abstract]
• Kwan, A, Winefield, R, Sunde, M, Matthews, J, Haverkamp, R, Templeton, M, Mackay, J. Structural basis for rodlet assembly in fungal hydrophobins. Proceedings of the National Academy of Sciences of the United States of America. 2006; 103:3621-6 [Abstract]
• Lowry, J, Mackay, J. GATA-1: one protein, many partners. The international journal of biochemistry & cell biology. 2006; 38:6-11 [Abstract]

• Pursglove, S, Mackay, J. CSL: a notch above the rest. The international journal of biochemistry & cell biology. 2005; 37:2472-7 [Abstract]
• Lee, C, Nancarrow, A, Bach, I, Mackay, J, Matthews, J. 1H, 15N and 13C assignments of an intramolecular Lhx3:ldb1 complex. Journal of biomolecular NMR. 2005. p. 198. [Abstract]
• Porter, C, Wilce, M, Mackay, J, Leedman, P, Wilce, J. Grb7-SH2 domain dimerisation is affected by a single point mutation. European biophysics journal : EBJ. 2005; 34:454-60 [Abstract]
• Feng, L, Zhou, S, Gu, L, Gell, D, Mackay, J, Weiss, M, Gow, A, Shi, Y. Structure of oxidized alpha-haemoglobin bound to AHSP reveals a protective mechanism for haem. Nature. 2005; 435:697-701 [Abstract]
• Mackay, J, Muiznieks, L, Toonkool, P, Weiss, A. The hydrophobic domain 26 of human tropoelastin is unstructured in solution. Journal of structural biology. 2005; 150:154-62 [Abstract]
• Duggin, I, Matthews, J, Dixon, N, Wake, R, Mackay, J. A complex mechanism determines polarity of DNA replication fork arrest by the replication terminator complex of Bacillus subtilis. The Journal of biological chemistry. 2005; 280:13105-13 [Abstract]
• Kwan, A, Fairley, K, Anderberg, P, Liew, C, Harding, M, Mackay, J. Solution structure of a recombinant type I sculpin antifreeze protein. Biochemistry. 2005; 44:1980-8 [Abstract]
• Sharpe, B, Liew, C, Kwan, A, Wilce, J, Crossley, M, Matthews, J, Mackay, J. Assessment of the robustness of a serendipitous zinc binding fold: mutagenesis and protein grafting. Structure (London, England). 2005; 13:257-66 [Abstract]
• Liew, C, Simpson, R, Kwan, A, Crofts, L, Loughlin, F, Matthews, J, Crossley, M, Mackay, J. Zinc fingers as protein recognition motifs: structural basis for the GATA-1/friend of GATA interaction. Proceedings of the National Academy of Sciences of the United States of America. 2005; 102:583-8 [Abstract]
• Weiss, M, Zhou, S, Feng, L, Gell, D, Mackay, J, Shi, Y, Gow, A. Role of Alpha Hemoglobin-Stabilizing Protein in Normal Erythropoiesis and {beta}-Thalassemia. Annals of the New York Academy of Sciences. 2005; 1054:103-17 [Abstract]

• Feng, L, Gell, D, Zhou, S, Gu, L, Kong, Y, Li, J, Hu, M, Yan, N, Lee, C, Rich, A, Armstrong, R, Lay, P, Gow, A, Weiss, M, Mackay, J, Shi, Y. Molecular mechanism of AHSP-mediated stabilization of alpha-hemoglobin. Cell. 2004; 119:629-40 [Abstract]
• Kong, Y, Zhou, S, Kihm, A, Katein, A, Yu, X, Gell, D, Mackay, J, Adachi, K, Foster-Brown, L, Louden, C, Gow, A, Weiss, M. Loss of alpha-hemoglobin-stabilizing protein impairs erythropoiesis and exacerbates beta-thalassemia. The Journal of clinical investigation. 2004; 114:1457-66 [Abstract]
• Westman, B, Perdomo, J, Matthews, J, Crossley, M, Mackay, J. Structural studies on a protein-binding zinc-finger domain of Eos reveal both similarities and differences to classical zinc fingers. Biochemistry. 2004; 43:13318-27 [Abstract]
• Chow, M, Mackay, J, Whisstock, J, Scanlon, M, Bottomley, S. Structural and functional analysis of the Josephin domain of the polyglutamine protein ataxin-3. Biochemical and biophysical research communications. 2004; 322:387-94 [Abstract]
• Simpson, R, Yi Lee, S, Bartle, N, Sum, E, Visvader, J, Matthews, J, Mackay, J, Crossley, M. A classic zinc finger from friend of GATA mediates an interaction with the coiled-coil of transforming acidic coiled-coil 3. The Journal of biological chemistry. 2004; 279:39789-97 [Abstract]
• Dastmalchi, S, Church, W, Morris, M, Iismaa, T, Mackay, J. Presence of transient helical segments in the galanin-like peptide evident from (1)H NMR, circular dichroism, and prediction studies. Journal of structural biology. 2004; 146:261-71 [Abstract]
• Sunde, M, McGrath, K, Young, L, Matthews, J, Chua, E, Mackay, J, Death, A. TC-1 is a novel tumorigenic and natively disordered protein associated with thyroid cancer. Cancer research. 2004; 64:2766-73 [Abstract]
• Donadini, R, Liew, C, Kwan, A, Mackay, J, Fields, B. Crystal and solution structures of a superantigen from Yersinia pseudotuberculosis reveal a jelly-roll fold. Structure (London, England : 1993). 2004; 12:145-56 [Abstract]

• Westman, B, Perdomo, J, Sunde, M, Crossley, M, Mackay, J. The C-terminal domain of Eos forms a high order complex in solution. The Journal of biological chemistry. 2003; 278:42419-26 [Abstract]
• Kwan, A, Czolij, R, Mackay, J, Crossley, M. Pentaprobe: a comprehensive sequence for the one-step detection of DNA-binding activities. Nucleic acids research. 2003; 31:e124 [Abstract]
• Simpson, R, Cram, E, Czolij, R, Matthews, J, Crossley, M, Mackay, J. CCHX zinc finger derivatives retain the ability to bind Zn(II) and mediate protein-DNA interactions. The Journal of biological chemistry. 2003; 278:28011-8 [Abstract]
• Kwan, A, Gell, D, Verger, A, Crossley, M, Matthews, J, Mackay, J. Engineering a protein scaffold from a PHD finger. Structure (London, England : 1993). 2003; 11:803-13 [Abstract]
• Deane, J, Mackay, J, Kwan, A, Sum, E, Visvader, J, Matthews, J. Structural basis for the recognition of ldb1 by the N-terminal LIM domains of LMO2 and LMO4. The EMBO journal. 2003; 22:2224-33 [Abstract]

• Gell, D, Kong, Y, Eaton, S, Weiss, M, Mackay, J. Biophysical characterization of the alpha-globin binding protein alpha-hemoglobin stabilizing protein. The Journal of biological chemistry. 2002; 277:40602-9 [Abstract]
• Westman, B, Mackay, J, Gell, D. Ikaros: a key regulator of haematopoiesis. The international journal of biochemistry & cell biology. 2002; 34:1304-7 [Abstract]
• Kowalski, K, Liew, C, Matthews, J, Gell, D, Crossley, M, Mackay, J. Characterization of the conserved interaction between GATA and FOG family proteins. The Journal of biological chemistry. 2002; 277:35720-9 [Abstract]
• Chen, F, Kook, H, Milewski, R, Gitler, A, Lu, M, Li, J, Nazarian, R, Schnepp, R, Jen, K, Biben, C, Runke, G, Mackay, J, Novotny, J, Schwartz, R, Harvey, R, Mullins, M, Epstein, J. Hop is an unusual homeobox gene that modulates cardiac development. Cell. 2002; 110:713-23 [Abstract]
• Fairley, K, Westman, B, Pham, L, Haymet, A, Harding, M, Mackay, J. Type I shorthorn sculpin antifreeze protein: recombinant synthesis, solution conformation, and ice growth inhibition studies. The Journal of biological chemistry. 2002; 277:24073-80 [Abstract]
• Deane, J, Visvader, J, Mackay, J, Matthew, J. 1H, 15N and 13C assignments of FLIN4, an intramolecular LMO4:ldb1 complex. Journal of biomolecular NMR. 2002. p. 165-6. [Abstract]
• Sharpe, B, Matthews, J, Kwan, A, Newton, A, Gell, D, Crossley, M, Mackay, J. A new zinc binding fold underlines the versatility of zinc binding modules in protein evolution. Structure (London, England : 1993). 2002; 10:639-48 [Abstract]
• Robson, S, Michie, K, Mackay, J, Harry, E, King, G. The Bacillus subtilis cell division proteins FtsL and DivIC are intrinsically unstable and do not interact with one another in the absence of other septasomal components. Molecular microbiology. 2002; 44:663-74 [Abstract]
• Liepinsh, E, Otting, G, Harding, M, Ward, L, Mackay, J, Haymet, A. Solution structure of a hydrophobic analogue of the winter flounder antifreeze protein. European journal of biochemistry / FEBS. 2002; 269:1259-66 [Abstract]
• Pursglove, S, Mulhern, T, Mackay, J, Hinds, M, Booker, G. The solution structure and intramolecular associations of the Tec kinase SRC homology 3 domain. The Journal of biological chemistry. 2002; 277:755-62 [Abstract]
• Polekhina, G, House, C, Traficante, N, Mackay, J, Relaix, F, Sassoon, D, Parker, M, Bowtell, D. Siah ubiquitin ligase is structurally related to TRAF and modulates TNF-alpha signaling. Nature structural biology. 2002; 9:68-75 [Abstract]

• Matthews, J, Visvader, J, Mackay, J. 1H, 15N and 13C assignments of FLIN2, an intramolecular LMO2:ldb1 complex. Journal of biomolecular NMR. 2001. p. 385-6. [Abstract]
• Newton, A, Mackay, J, Crossley, M. The N-terminal zinc finger of the erythroid transcription factor GATA-1 binds GATC motifs in DNA. The Journal of biological chemistry. 2001; 276:35794-801 [Abstract]
• Deane, J, Sum, E, Mackay, J, Lindeman, G, Visvader, J, Matthews, J. Design, production and characterization of FLIN2 and FLIN4: the engineering of intramolecular ldb1:LMO complexes. Protein engineering. 2001; 14:493-9 [Abstract]
• Proudfoot, E, Mackay, J, Karuso, P. Probing site specificity of DNA binding metallointercalators by NMR spectroscopy and molecular modeling. Biochemistry. 2001; 40:4867-78 [Abstract]
• Mackay, J, Matthews, J, Winefield, R, Mackay, L, Haverkamp, R, Templeton, M. The hydrophobin EAS is largely unstructured in solution and functions by forming amyloid-like structures. Structure (London, England : 1993). 2001; 9:83-91 [Abstract]
• Wang, X, Connor, M, Wilson, D, Wilson, H, Nicholson, G, Smith, R, Shaw, D, Mackay, J, Alewood, P, Christie, M, King, G. Discovery and structure of a potent and highly specific blocker of insect calcium channels. Journal of Biological Chemistry. 2001; 60:637-646

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