Associate Professor Jacqueline Matthews

Sylvia and Charles Viertel Senior Medical Research Fellow Molecular and Microbial Biosciences Faculty of Science G08 - Biochemistry and Microbiology Building The University of Sydney NSW 2006 Australia Email Phone x16025 Fax x14726  Related Website		Quick Links List Profiles Update Your Profile How to update your profile

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Research Interests

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• Lowry, J, Gamsjaeger, R, Thong, S, Hung, W, Kwan, A, Broitman-Maduro, G, Matthews, J, Maduro, M, Mackay, J. Structural analysis of med-1 reveals unexpected diversity in the mechanism of DNA recognition by gata-type zinc finger domains. The Journal of biological chemistry. 2009; 284:5827-35 [Abstract]

• Pilotelle-Bunner, A, Matthews, J, Cornelius, F, Apell, H, Sebban, P, Clarke, R. ATP Binding Equilibria of the Na(+),K(+)-ATPase (dagger). Biochemistry. 2008; 47:13103-13114 [Abstract]
• Matthews, J, Bhati, M, Craig, V, Deane, J, Jeffries, C, Lee, C, Nancarrow, A, Ryan, D, Sunde, M. Competition between LIM-binding domains. Biochemical Society Transactions. 2008; 36:1393-1397 [Abstract]
• Matthews, J, Loughlin, F, Mackay, J. Designed metal-binding sites in biomolecular and bioinorganic interactions. Current opinion in structural biology. 2008; 18:484-90 [Abstract]
• Bhati, M, Lee, C, Nancarrow, A, Lee, M, Craig, V, Bach, I, Guss, J, Mackay, J, Matthews, J. Implementing the LIM code: the structural basis for cell type-specific assembly of LIM-homeodomain complexes. The EMBO journal. 2008; 27:2018-29 [Abstract]
• Bhati, M, Lee, M, Nancarrow, A, Bach, I, Guss, J, Matthews, J. Crystallization of an Lhx3-Isl1 complex. Acta crystallographica. Section F, Structural biology and crystallization communications. 2008; 64:297-299 [Abstract]

• Chong, S, Vickaryous, N, Ashe, A, Zamudio, N, Youngson, N, Hemley, S, Stopka, T, Skoultchi, A, Matthews, J, Scott, H, de Kretser, D, O'Bryan, M, Blewitt, M, Whitelaw, E. Modifiers of epigenetic reprogramming show paternal effects in the mouse. Nature genetics. 2007; 39:614-622 [Abstract]
• Stokes, P, Thompson, L, Marianayagam, N, Matthews, J. Dimerization of CtIP may stabilize in vivo interactions with the Retinoblastoma-pocket domain. Biochemical and biophysical research communications. 2007; 354:197-202 [Abstract]

• Begg, G, Carrington, L, Stokes, P, Matthews, J, Wouters, M, Husain, A, Lorand, L, Iismaa, S, Graham, R. Mechanism of allosteric regulation of transglutaminase 2 by GTP. Proceedings of the National Academy of Sciences of the United States of America. 2006; 103:19683-8 [Abstract]
• Jeffries, C, Graham, S, Stokes, P, Collyer, C, Guss, J, Matthews, J. Stabilization of a binary protein complex by intein-mediated cyclization. Protein science : a publication of the Protein Society. 2006; 15:2612-8 [Abstract]
• Ryan, D, Sunde, M, Kwan, A, Marianayagam, N, Nancarrow, A, Vanden Hoven, R, Thompson, L, Baca, M, Mackay, J, Visvader, J, Matthews, J. Identification of the key LMO2-binding determinants on Ldb1. Journal of molecular biology. 2006; 359:66-75 [Abstract]
• Begg, G, Holman, S, Stokes, P, Matthews, J, Graham, R, Iismaa, S. Mutation of a critical arginine in the GTP-binding site of transglutaminase 2 disinhibits intracellular cross-linking activity. The Journal of biological chemistry. 2006; 281:12603-9 [Abstract]
• Ely, L, Beddoe, T, Clements, C, Matthews, J, Purcell, A, Kjer-Nielsen, L, McCluskey, J, Rossjohn, J. Disparate thermodynamics governing T cell receptor-MHC-I interactions implicate extrinsic factors in guiding MHC restriction. Proceedings of the National Academy of Sciences of the United States of America. 2006; 103:6641-6 [Abstract]
• Kwan, A, Winefield, R, Sunde, M, Matthews, J, Haverkamp, R, Templeton, M, Mackay, J. Structural basis for rodlet assembly in fungal hydrophobins. Proceedings of the National Academy of Sciences of the United States of America. 2006; 103:3621-6 [Abstract]

• Lee, C, Nancarrow, A, Bach, I, Mackay, J, Matthews, J. 1H, 15N and 13C assignments of an intramolecular Lhx3:ldb1 complex. Journal of biomolecular NMR. 2005. p. 198. [Abstract]
• Ryan, D, Matthews, J. Protein-protein interactions in human disease. Current opinion in structural biology. 2005; 15:441-6 [Abstract]
• Duggin, I, Matthews, J, Dixon, N, Wake, R, Mackay, J. A complex mechanism determines polarity of DNA replication fork arrest by the replication terminator complex of Bacillus subtilis. The Journal of biological chemistry. 2005; 280:13105-13 [Abstract]
• Williams, N, Liepinsh, E, Watt, S, Prosselkov, P, Matthews, J, Attard, P, Beck, J, Dixon, N, Otting, G. Stabilization of native protein fold by intein-mediated covalent cyclization. Journal of Molecular Biology. 2005; 346:1095-1108 [Abstract]
• Sharpe, B, Liew, C, Kwan, A, Wilce, J, Crossley, M, Matthews, J, Mackay, J. Assessment of the robustness of a serendipitous zinc binding fold: mutagenesis and protein grafting. Structure (London, England). 2005; 13:257-66 [Abstract]
• Liew, C, Simpson, R, Kwan, A, Crofts, L, Loughlin, F, Matthews, J, Crossley, M, Mackay, J. Zinc fingers as protein recognition motifs: structural basis for the GATA-1/friend of GATA interaction. Proceedings of the National Academy of Sciences of the United States of America. 2005; 102:583-8 [Abstract]

• Sunde, M, McGrath, K, Young, L, Matthews, J, Chua, E, Mackay, J, Death, A. TC-1 is a novel tumorigenic and natively disordered protein associated with thyroid cancer. Cancer research. 2004; 64:2766-73 [Abstract]

• Matthews, J, Visvader, J. LIM-domain-binding protein 1: a multifunctional cofactor that interacts with diverse proteins. EMBO reports. 2003; 4:1132-1137 [Abstract]
• Deane, J, Maher, M, Langley, D, Graham, S, Visvader, J, Guss, J, Matthews, J. Crystallization of FLINC4, an intramolecular LMO4-ldb1 complex. Acta crystallographica. Section D, Biological crystallography. 2003; 59:1484-1486 [Abstract]
• Simpson, R, Cram, E, Czolij, R, Matthews, J, Crossley, M, Mackay, J. CCHX zinc finger derivatives retain the ability to bind Zn(II) and mediate protein-DNA interactions. The Journal of biological chemistry. 2003; 278:28011-8 [Abstract]
• Kwan, A, Gell, D, Verger, A, Crossley, M, Matthews, J, Mackay, J. Engineering a protein scaffold from a PHD finger. Structure (London, England : 1993). 2003; 11:803-13 [Abstract]
• Deane, J, Mackay, J, Kwan, A, Sum, E, Visvader, J, Matthews, J. Structural basis for the recognition of ldb1 by the N-terminal LIM domains of LMO2 and LMO4. The EMBO journal. 2003; 22:2224-33 [Abstract]
• Turner, J, Nicholas, H, Bishop, D, Matthews, J, Crossley, M. The LIM protein FHL3 binds basic Krüppel-like factor/Krüppel-like factor 3 and its co-repressor C-terminal-binding protein 2. The Journal of biological chemistry. 2003; 278:12786-95 [Abstract]

• Matthews, J, Sunde, M. Zinc fingers--folds for many occasions. IUBMB life. 2002; 54:351-5 [Abstract]
• Kowalski, K, Liew, C, Matthews, J, Gell, D, Crossley, M, Mackay, J. Characterization of the conserved interaction between GATA and FOG family proteins. The Journal of biological chemistry. 2002; 277:35720-9 [Abstract]
• Deane, J, Visvader, J, Mackay, J, Matthew, J. 1H, 15N and 13C assignments of FLIN4, an intramolecular LMO4:ldb1 complex. Journal of biomolecular NMR. 2002. p. 165-6. [Abstract]
• Sharpe, B, Matthews, J, Kwan, A, Newton, A, Gell, D, Crossley, M, Mackay, J. A new zinc binding fold underlines the versatility of zinc binding modules in protein evolution. Structure (London, England : 1993). 2002; 10:639-48 [Abstract]

• Matthews, J, Visvader, J, Mackay, J. 1H, 15N and 13C assignments of FLIN2, an intramolecular LMO2:ldb1 complex. Journal of biomolecular NMR. 2001. p. 385-6. [Abstract]
• Bradstock, K, Matthews, J, Young, G, Lowenthal, R, Baxter, H, Arthur, C, Bashford, J, Brighton, T, Cannell, P, Dunlop, L, Durrant, S, Enno, A, Eliadis, P, Gill, D, Gillett, A, Gottlieb, D, Januszewicz, H, Joshua, D, Leahy, M, Schwarer, A, Taylor, K, , A. Effects of glycosylated recombinant human granulocyte colony-stimulating factor after high-dose cytarabine-based induction chemotherapy for adult acute myeloid leukaemia. Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 2001; 15:1331-8 [Abstract]
• Deane, J, Sum, E, Mackay, J, Lindeman, G, Visvader, J, Matthews, J. Design, production and characterization of FLIN2 and FLIN4: the engineering of intramolecular ldb1:LMO complexes. Protein engineering. 2001; 14:493-9 [Abstract]
• Mackay, J, Matthews, J, Winefield, R, Mackay, L, Haverkamp, R, Templeton, M. The hydrophobin EAS is largely unstructured in solution and functions by forming amyloid-like structures. Structure (London, England : 1993). 2001; 9:83-91 [Abstract]

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