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Professor Jules Mitchell Guss

Professor
Molecular and Microbial Biosciences
Faculty of Science

G08 - Biochemistry and Microbiology Building
The University of Sydney
NSW 2006 Australia

Email
Phone +61 2 9351 4302
Fax +61 2 9351 4726
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Research Interests

Mitchell Guss has a long standing interest in the application of the tools of structural biology to understand how biological molecules work and how they can be exploited for medical and other purposes.

Select Publications

    2009
    • McGrath, A, Hilmer, K, Collyer, C, Shepard, E, Elmore, B, Brown, D, Dooley, D, Guss, J. Structure and inhibition of human diamine oxidase. Biochemistry. 2009; 48:9810-22 [Abstract]
    • Jacques, D, Streamer, M, Rowland, S, King, G, Guss, J, Trewhella, J, Langley, D. Structure of the sporulation histidine kinase inhibitor Sda from Bacillus subtilis and insights into its solution state. Acta crystallographica. Section D, Biological crystallography. 2009; 65:574-581 [Abstract]
    • Loughlin, F, Mansfield, R, Vaz, P, McGrath, A, Setiyaputra, S, Gamsjaeger, R, Chen, E, Morris, B, Guss, J, Mackay, J. The zinc fingers of the SR-like protein ZRANB2 are single-stranded RNA-binding domains that recognize 5' splice site-like sequences. Proceedings of the National Academy of Sciences of the United States of America. 2009; 106:5581-5586 [Abstract]
    • Langley, D, Shojaei, M, Chan, C, Lok, H, Mackay, J, Traut, T, Guss, J, Christopherson, R. Structure and Inhibition of Orotidine 5'-Monophosphate Decarboxylase from Plasmodium falciparum. Biochemistry. 2009; 48:2570 [Abstract]
    • Lee, M, del Rosario, M, Harris, H, Blankenship, R, Guss, J, Freeman, H. The crystal structure of auracyanin A at 1.85 A resolution: the structures and functions of auracyanins A and B, two almost identical "blue" copper proteins, in the photosynthetic bacterium Chloroflexus aurantiacus. Journal of Biological Inorganic Chemistry. 2009; 14:329-345 [Abstract]
    • Gadd, M, Langley, D, Guss, J, Matthews, J. Crystallization and diffraction of an Lhx4-Isl2 complex. Acta crystallographica. Section F, Structural biology and crystallization communications. 2009; 65:151-153 [Abstract]
    • Guss, J. Hans C. Freeman (1929-2008). Acta crystallographica. Section D, Biological crystallography. 2009; 65:93-95 [Abstract]
    2008
    • Jacques, D, Langley, D, Jeffries, C, Cunnigham, K, Burkholder, W, Guss, J, Trewhella, J. Histidine Kinase Regulation by a Cyclophilin-like Inhibitor. Journal of molecular biology. 2008; 384:422-35 [Abstract]
    • Loughlin, F, Lee, M, Guss, J, Mackay, J. Crystallization of a ZRANB2-RNA complex. Acta crystallographica. Section F, Structural biology and crystallization communications. 2008; 64:1175-1177 [Abstract]
    • Bhati, M, Lee, C, Nancarrow, A, Lee, M, Craig, V, Bach, I, Guss, J, Mackay, J, Matthews, J. Implementing the LIM code: the structural basis for cell type-specific assembly of LIM-homeodomain complexes. The EMBO journal. 2008; 27:2018-29 [Abstract]
    • Langley, D, Trambaiolo, D, Duff, A, Dooley, D, Freeman, H, Guss, J. Complexes of the copper-containing amine oxidase from Arthrobacter globiformis with the inhibitors benzylhydrazine and tranylcypromine. Acta crystallographica. Section F, Structural biology and crystallization communications. 2008; 64:577-83 [Abstract]
    • Langley, D, Brown, D, Cheruzel, L, Contakes, S, Duff, A, Hilmer, K, Dooley, D, Gray, H, Guss, J, Freeman, H. Enantiomer-specific binding of ruthenium(II) molecular wires by the amine oxidase of Arthrobacter globiformis. Journal of the American Chemical Society. 2008; 130:8069-78 [Abstract]
    • Langley, D, Shojaei, M, Chan, C, Lok, H, Mackay, J, Traut, T, Guss, J, Christopherson, R. Structure and inhibition of orotidine 5'-monophosphate decarboxylase from Plasmodium falciparum. Biochemistry. 2008; 47:3842-3854 [Abstract]
    • Langley, D, Harty, D, Jacques, N, Hunter, N, Guss, J, Collyer, C. Structure of N-acetyl-beta-D-glucosaminidase (GcnA) from the Endocarditis Pathogen Streptococcus gordonii and its Complex with the Mechanism-based Inhibitor NAG-thiazoline. Journal of molecular biology. 2008; 377:104-16 [Abstract]
    • Graham, S, Guss, M. Complexes of mutants of Escherichia coli aminopeptidase P and the tripeptide substrate ValProLeu. Archives of Biochemistry and Biophysics. 2008; 469:200-208
    2007
    • Lee, M, Maher, M, Christopherson, R, Guss, J. Kinetic and Structural Analysis of Mutant Escherichia coli Dihydroorotases: A Flexible Loop Stabilizes the Transition State(,). Biochemistry. 2007; 46:10538-50 [Abstract]
    • Lee, M, Chan, C, Graham, S, Christopherson, R, Guss, J, Maher, M. Structures of Ligand-free and Inhibitor Complexes of Dihydroorotase from Escherichia coli: Implications for Loop Movement in Inhibitor Design. Journal of molecular biology. 2007; 370:812-825 [Abstract]
    • Whitten, A, Jacques, D, Hammouda, B, Hanley, T, King, G, Guss, J, Trewhella, J, Langley, D. The structure of the KinA-Sda complex suggests an allosteric mechanism of histidine kinase inhibition. Journal of molecular biology. 2007; 368:407-20 [Abstract]
    2006
    • Jeffries, C, Graham, S, Stokes, P, Collyer, C, Guss, J, Matthews, J. Stabilization of a binary protein complex by intein-mediated cyclization. Protein science : a publication of the Protein Society. 2006; 15:2612-8 [Abstract]
    • Graham, S, Lilley, P, Lee, M, Schaeffer, P, Kralicek, A, Dixon, N, Guss, J. Kinetic and crystallographic analysis of mutant Escherichia coli aminopeptidase P: insights into substrate recognition and the mechanism of catalysis. Biochemistry. 2006; 45:964-75 [Abstract]
    2005
    • Graham, S, Bond, C, Freeman, H, Guss, J. Structural and functional implications of metal ion selection in aminopeptidase P, a metalloprotease with a dinuclear metal center. Biochemistry. 2005; 44:13820-36 [Abstract]
    • Contakes, S, Juda, G, Langley, D, Halpern-Manners, N, Duff, A, Dunn, A, Gray, H, Dooley, D, Guss, J, Freeman, H. Reversible inhibition of copper amine oxidase activity by channel-blocking ruthenium(II) and rhenium(I) molecular wires. Proceedings of the National Academy of Sciences of the United States of America. 2005; 102:13451-6 [Abstract]
    • Sträter, N, Jasper, B, Scholte, M, Krebs, B, Duff, A, Langley, D, Han, R, Averill, B, Freeman, H, Guss, J. Crystal structures of recombinant human purple Acid phosphatase with and without an inhibitory conformation of the repression loop. Journal of molecular biology. 2005; 351:233-46 [Abstract]
    • Lee, M, Chan, C, Mitchell Guss, J, Christopherson, R, Maher, M. Dihydroorotase from Escherichia coli: loop movement and cooperativity between subunits. Journal of molecular biology. 2005; 348:523-33 [Abstract]
    2004
    • Duff, A, Trambaiolo, D, Cohen, A, Ellis, P, Juda, G, Shepard, E, Langley, D, Dooley, D, Freeman, H, Guss, J. Using xenon as a probe for dioxygen-binding sites in copper amine oxidases. Journal of molecular biology. 2004; 344:599-607 [Abstract]
    • Langley, D, Harty, D, Graham, S, Guss, J, Hunter, N, Collyer, C. Crystallization of GcnA, an N-acetyl-beta-D-glucosaminidase, from Streptococcus gordonii. Acta crystallographica. Section D, Biological crystallography. 2004; 60:1910-1 [Abstract]
    • Graham, S, Maher, M, Simmons, W, Freeman, H, Guss, J. Structure of Escherichia coli aminopeptidase P in complex with the inhibitor apstatin. Acta crystallographica. Section D, Biological crystallography. 2004; 60:1770-1779 [Abstract]
    • Deane, J, Ryan, D, Sunde, M, Maher, M, Guss, J, Visvader, J, Matthews, J. Tandem LIM domains provide synergistic binding in the LMO4:Ldb1 complex. The EMBO journal. 2004; 23:3589-98 [Abstract]
    • O'Connell, K, Langley, D, Shepard, E, Duff, A, Jeon, H, Sun, G, Freeman, H, Guss, J, Sayre, L, Dooley, D. Differential inhibition of six copper amine oxidases by a family of 4-(aryloxy)-2-butynamines: evidence for a new mode of inactivation. Biochemistry. 2004; 43:10965-10978 [Abstract]
    • Adams, A, Guss, J, Denny, W, Wakelin, L. Structure of 9-amino-[N-(2-dimethylamino)propyl]acridine-4-carboxamide bound to d(CGTACG)(2): a comparison of structures of d(CGTACG)(2) complexed with intercalatorsin the presence of cobalt. Acta crystallographica. Section D, Biological crystallography. 2004; 60:823-828 [Abstract]
    • Maher, M, Ghosh, M, Grunden, A, Menon, A, Adams, M, Freeman, H, Guss, J. Structure of the prolidase from Pyrococcus furiosus. Biochemistry. 2004; 43:2771-2783 [Abstract]
    • Maher, M, Cross, M, Wilce, M, Guss, J, Wedd, A. Metal-substituted derivatives of the rubredoxin from Clostridium pasteurianum. Acta crystallographica. Section D, Biological crystallography. 2004; 60:298-303 [Abstract]
    2003
    • Duff, A, Cohen, A, Ellis, P, Kuchar, J, Langley, D, Shepard, E, Dooley, D, Freeman, H, Guss, J. The crystal structure of Pichia pastoris lysyl oxidase. Biochemistry. 2003; 42:15148-57 [Abstract]
    • Lee, M, Maher, M, Freeman, H, Guss, J. Auracyanin B structure in space group P6(5). Acta crystallographica. Section D, Biological crystallography. 2003; 59:1545-1550 [Abstract]
    • Deane, J, Maher, M, Langley, D, Graham, S, Visvader, J, Guss, J, Matthews, J. Crystallization of FLINC4, an intramolecular LMO4-ldb1 complex. Acta crystallographica. Section D, Biological crystallography. 2003; 59:1484-1486 [Abstract]
    • Graham, S, Lee, M, Freeman, H, Guss, J. An orthorhombic form of Escherichia coli aminopeptidase P at 2.4 A resolution. Acta crystallographica. Section D, Biological crystallography. 2003; 59:897-902 [Abstract]
    • Maher, M, Huang, D, Guss, J, Collyer, C, Christopherson, R. Crystallization of hamster dihydroorotase: involvement of a disulfide-linked tetrameric form. Acta crystallographica. Section D, Biological crystallography. 2003; 59:381-384 [Abstract]
    2002
    • Lee, M, Willingham, K, Langley, D, Maher, M, Cohen, A, Ellis, P, Kuchar, J, Dooley, D, Freeman, H, Guss, J. Crystallization of Pichia pastoris lysyl oxidase. Acta crystallographica. Section D, Biological crystallography. 2002; 58:2177-9 [Abstract]
    • Adams, A, Guss, J, Denny, W, Wakelin, L. Crystal structure of 9-amino-N-[2-(4-morpholinyl)ethyl]-4-acridinecarboxamide bound to d(CGTACG)2: implications for structure-activity relationships of acridinecarboxamide topoisomerase poisons. Nucleic acids research. 2002; 30:719-25 [Abstract]
    2001
    • Bond, C, Blankenship, R, Freeman, H, Guss, J, Maher, M, Selvaraj, F, Wilce, M, Willingham, K. Crystal structure of auracyanin, a "blue" copper protein from the green thermophilic photosynthetic bacterium Chloroflexus aurantiacus. Journal of molecular biology. 2001; 306:47-67 [Abstract]

    Publication Keywords

    Oxygen; enzyme structure; metalloproteins; histidine kinase; Xenon; Archaeal Proteins; Dipeptidases; Pyrococcus furiosus