Dr Nick Coleman
Lecturer in Microbiology G08 - Biochemistry and Microbiology Building
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Research is in the areas of environmental microbiology and biotechnology, with a particular focus on molecular genetic analysis of bacteria capable of degrading pollutants. Applications of this work include the bioremediation of contaminated sites and the development of bacterial biocatalysts for other purposes (eg. pharmaceutical synthesis). Microorganisms able to biodegrade toxic pollutants are intrinsically interesting due to what they can teach us about evolution – especially the ways in which Nature adapts to meet chemical challenges. This work increasingly involves analysis of mobile genetic elements (MGEs, eg. plasmids), which are key players in bacterial adaptation to both industrial pollutants and antibiotics. A better understanding of MGEs would allow us to better predict and manage bacterial evolution, whether this is controlling the spread of antibiotic resistance, understanding the fate of recombinant DNA in the environment, or harnessing the power of MGEs for biotechnology. Other areas of interest include metagenomics, microbial ecology and diversity, and agricultural microbiology.
- Mattes, T, Alexander, A, Richardson, P, Munk, A, Han, C, Stothard, P, Coleman, N. The genome of Polaromonas sp. strain JS666: insights into the evolution of a hydrocarbon- and xenobiotic-degrading bacterium, and features of relevance to biotechnology. Applied and environmental microbiology. 2008; 74:6405-16 [Abstract]
- Holmes, A, Coleman, N. Evolutionary ecology and multidisciplinary approaches to prospecting for monooxygenases as biocatalysts. Antonie van Leeuwenhoek. 2008; 94:75-84 [Abstract]
- Mattes, T, Coleman, N, Chuang, A, Rogers, A, Spain, J, Gossett, J. Mechanism controlling the extended lag period associated with vinyl chloride starvation in Nocardioides sp. strain JS614. Archives of microbiology. 2007; 187:217-26 [Abstract]
- Priestley, J, Coleman, N, Duxbury, T. Growth rate and nutrient limitation affect the transport of Rhodococcus sp strain DN22 through sand. Biodegradation. 2006; 17:571-576 [Abstract]
- Coleman, N, Bui, N, Holmes, A. Soluble di-iron monooxygenase gene diversity in soils, sediments and ethene enrichments. Environmental microbiology. 2006; 8:1228-39 [Abstract]
- Coleman, N, Holmes, A. The native Pseudomonas stutzeri strain Q chromosomal integron can capture and express cassette-associated genes. Microbiology (Reading, England). 2005; 151:1853-64 [Abstract]
- Mattes, T, Coleman, N, Spain, J, Gossett, J. Physiological and molecular genetic analyses of vinyl chloride and ethene biodegradation in Nocardioides sp strain JS614. Archives of Microbiology. 2005; 183:95-106 [Abstract]
- Coleman, N, Spain, J. Distribution of the coenzyme M pathway of epoxide metabolism among ethene- and vinyl chloride-degrading Mycobacterium strains. Applied and environmental microbiology. 2003; 69:6041-6 [Abstract]
- Coleman, N, Spain, J. Epoxyalkane: coenzyme M transferase in the ethene and vinyl chloride biodegradation pathways of mycobacterium strain JS60. Journal of bacteriology. 2003; 185:5536-45 [Abstract]
- Coleman, N, Mattes, T, Gossett, J, Spain, J. Phylogenetic and kinetic diversity of aerobic vinyl chloride-assimilating bacteria from contaminated sites. Applied and environmental microbiology. 2002; 68:6162-71 [Abstract]
- Coleman, N, Mattes, T, Gossett, J, Spain, J. Biodegradation of cis-dichloroethene as the sole carbon source by a beta-proteobacterium. Applied and environmental microbiology. 2002; 68:2726-30 [Abstract]
- Coleman, N, Spain, J, Duxbury, T. Evidence that RDX biodegradation by Rhodococcus strain DN22 is plasmid-borne and involves a cytochrome p-450. Journal of applied microbiology. 2002; 93:463-72 [Abstract]
Evolution; Bacteria; Biotechnology; Plasmids; Integrons; Pseudomonas stutzeri; Environmental Microbiology