Professor Peter Reeves
Professor G08 - Biochemistry and Microbiology Building
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The Reeves lab work on bacterial pathogenesis and evolution.
The species chosen for all of the work include pathogenic forms. All are important pathogens, but all are also very convenient for studying evolution as they include non-pathogenic forms. There are also good collections of strains available and usually a lot of data on diversity because of serotyping etc., both very helpful for sorting out the relationships of strains and the steps involved in development of pathogenicity for example
Recent publications have looked at the relationships of the major pathogenic clones of V. cholerae, the genetic basis of the 90 different capsules on the surface of Streptococcus pneumoniae and the overall population structure of E. coli, which gave insights into the origins of the different pathogenic forms.
Projects in the lab usually cover a particular aspect of a species or group of related species, and most involve a mix of lab work and DNA sequence.
The species chosen for all of the work include pathogenic forms. All are important pathogens, but all are also very convenient for studying evolution as they include non-pathogenic forms. There are also good collections of strains available and usually a lot of data on diversity because of serotyping etc., both very helpful for sorting out the relationships of strains and the steps involved in development of pathogenicity for example
Recent publications have looked at the relationships of the major pathogenic clones of V. cholerae, the genetic basis of the 90 different capsules on the surface of Streptococcus pneumoniae and the overall population structure of E. coli, which gave insights into the origins of the different pathogenic forms.
Projects in the lab usually cover a particular aspect of a species or group of related species, and most involve a mix of lab work and DNA sequence.
- Lan, R, Reeves, P, Octavia, S. Population structure, origins and evolution of major Salmonella enterica clones. Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases. 2009; 9:996-1005 [Abstract]
- Cunneen, M, De Castro, C, Kenyon, J, Parrilli, M, Reeves, P, Molinaro, A, Holst, O, Skurnik, M. The O-specific polysaccharide structure and biosynthetic gene cluster of Yersinia pseudotuberculosis serotype O:11. Carbohydrate research. 2009; 344:1533-40 [Abstract]
- Chan, W, Maharjan, R, Reeves, P, Sintchenko, V, Gilbert, G, Lan, R. Rapid and accurate typing of Bordetella pertussis targeting genes encoding acellular vaccine antigens using real time PCR and High Resolution Melt analysis. Journal of microbiological methods. 2009; 77:326-329 [Abstract]
- Ferenci, T, Zhou, Z, Betteridge, T, Ren, Y, Liu, Y, Feng, L, Reeves, P, Wang, L. Genomic sequencing reveals regulatory mutations and recombinational events in the widely used MC4100 lineage of Escherichia coli K-12. Journal of Bacteriology. 2009; 191:4025-4029 [Abstract]
- Tay, C, Reeves, P, Lan, R. Importation of the major pilin TcpA gene and frequent recombination drive the divergence of the Vibrio pathogenicity island in Vibrio cholerae. FEMS Microbiology Letters. 2008; 289:210-218 [Abstract]
- Cunneen, M, Reeves, P. Membrane topology of the Salmonella enterica serovar Typhimurium Group B O-antigen translocase Wzx. FEMS microbiology letters. 2008; 287:76-84 [Abstract]
- Liu, B, Knirel, Y, Feng, L, Perepelov, A, Senchenkova, S, Wang, Q, Reeves, P, Wang, L. Structure and genetics of Shigella O antigens. FEMS microbiology reviews. 2008; 32:627-653 [Abstract]
- Stevenson, G, Dieckelmann, M, Reeves, P. Determination of glycosyl transferase specificities for the E. coli O111 O antigen using a generic approach. Applied and environmental microbiology. 2008; 74:1294-8 [Abstract]
- Maharjan, R, Gu, C, Reeves, P, Sintchenko, V, Gilbert, G, Lan, R. Genome-wide analysis of single nucleotide polymorphisms in Bordetella pertussis using comparative genomic sequencing. Research in microbiology. 2008; 159:602-8 [Abstract]
- Feng, L, Reeves, P, Lan, R, Ren, Y, Gao, C, Zhou, Z, Ren, Y, Cheng, J, Wang, W, Wang, J, Qian, W, Li, D, Wang, L. A recalibrated molecular clock and independent origins for the cholera pandemic clones. PLoS ONE. 2008; 3:e4053 [Abstract]
- Stevenson, G, Dieckelmann, M, Reeves, P. Determination of Glycosyltransferase Specificities for the Escherichia coli O111 O Antigen by a Generic Approach. Applied and Environmental Microbiology. 2008; 74:1294-1298
- Mavroidi, A, Aanensen, D, Godoy, D, Skovsted, I, Kaltoft, M, Reeves, P, Bentley, S, Spratt, B. Genetic relatedness of the Streptococcus pneumoniae capsular biosynthetic loci. Journal of bacteriology. 2007; 189:7841-55 [Abstract]
- Aanensen, D, Mavroidi, A, Bentley, S, Reeves, P, Spratt, B. Predicted functions and linkage specificities of the products of the Streptococcus pneumoniae capsular biosynthetic loci. Journal of bacteriology. 2007; 189:7856-76 [Abstract]
- Wang, W, Perepelov, A, Feng, L, Shevelev, S, Wang, Q, Senchenkova, S, Han, W, Li, Y, Shashkov, A, Knirel, Y, Reeves, P, Wang, L. A group of Escherichia coli and Salmonella enterica O antigens sharing a common backbone structure. Microbiology (Reading, England). 2007; 153:2159-67 [Abstract]
- Cunneen, M, Reeves, P. The Yersinia kristensenii O11 O-antigen gene cluster was acquired by lateral gene transfer and incorporated at a novel chromosomal locus. Molecular biology and evolution. 2007; 24:1355-1365 [Abstract]
- Lan, R, Reeves, P. Amplified Fragment Lengeth Polymorphism analysis of Salmonella enterica Typhimurium. In: Salmonella: Methods and Protocols. United States: Humana Press Inc. 2007. p. 119-132.
- Feng, L, Perepelov, A, Zhao, G, Shevelev, S, Wang, Q, Senchenkova, S, Shashkov, A, Geng, Y, Reeves, P, Knirel, Y, Wang, L. Structural and genetic evidence that the Escherichia coli O148 O antigen is the precursor of the Shigella dysenteriae type 1 O antigen and identification of a glucosyltransferase gene. Microbiology (Reading, England). 2007; 153:139-47 [Abstract]
- Lan, R, Stevenson, G, Donohoe, K, Ward, L, Reeves, P. Molecular markers with potential to replace phage typing for Salmonella enterica serovar typhimurium. Journal of microbiological methods. 2007; 68:145-56 [Abstract]
- Wirth, T, Falush, D, Lan, R, Colles, F, Mensa, P, Wieler, L, Karch, H, Reeves, P, Maiden, M, Ochman, H, Achtman, M. Sex and virulence in Escherichia coli: an evolutionary perspective. Molecular Microbiology. 2006; 60:1136-1151 [Abstract]
- Bentley, S, Aanensen, D, Mavroidi, A, Saunders, D, Rabbinowitsch, E, Collins, M, Donohoe, K, Harris, D, Murphy, L, Quail, M, Samuel, G, Skovsted, I, Kaltoft, M, Barrell, B, Reeves, P, Parkhill, J, Spratt, B. Genetic analysis of the capsular biosynthetic locus from all 90 pneumococcal serotypes. Plos Genetics. 2006; 2:262-269 [Abstract]
- Hu, H, Lan, R, Reeves, P. Adaptation of multilocus sequencing for studying variation within a major clone: evolutionary relationships of Salmonella enterica serovar Typhimurium. Genetics. 2006; 172:743-750 [Abstract]
- Salim, A, Lan, R, Reeves, P. Vibrio cholerae pathogenic clones. Emerging infectious diseases. 2005; 11:1758-60 [Abstract]
- Tominaga, A, Lan, R, Reeves, P. Evolutionary changes of the flhDC flagellar master operon in Shigella strains. Journal of bacteriology. 2005; 187:4295-302 [Abstract]
- Senchenkova, S, Feng, L, Yang, J, Shashkov, A, Cheng, J, Liu, D, Knirel, Y, Reeves, P, Jin, Q, Ye, Q, Wang, L. Structural and genetic characterization of the Shigella boydii type 10 and type 6 O antigens. Journal of bacteriology. 2005; 187:2551-4 [Abstract]
- D'Souza, J, Samuel, G, Reeves, P. Evolutionary origins and sequence of the Escherichia coli O4 O-antigen gene cluster. FEMS microbiology letters. 2005; 244:27-32 [Abstract]
- Samuel, G, Reeves, P. Biosynthesis of O-antigens: genes and pathways involved in nucleotide sugar precursor synthesis and O-antigen assembly. Carbohydrate Research. 2003; 338:2503-2519 [Abstract]
Escherichia coli; Bacterial Proteins; O Antigens; Cholera; Vibrio cholerae; Shigella boydii; Shigella